Download PDF by Jacqueline A. Hubbard,Devin K. Binder: Astrocytes and Epilepsy

By Jacqueline A. Hubbard,Devin K. Binder

Epilepsy is a devastating crew of neurological problems characterised through periodic and unpredictable seizure job within the mind. there's a severe want for brand spanking new medications and ways given than not less than one-third of all epilepsy sufferers usually are not made freed from seizures by way of latest medicinal drugs and turn into "medically refractory". a lot of epilepsy study has involved in neuronal healing ambitions, yet present antiepileptic medications usually reason critical cognitive, developmental, and behavioral unintended effects. fresh findings point out a severe contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure job. in addition, many very important mobile and molecular adjustments happen in astrocytes in epileptic tissue in either people and animal types of epilepsy. The target of Astrocytes and Epilepsy is to comprehensively evaluate intriguing findings linking adjustments in astrocytes to sensible adjustments chargeable for epilepsy for the 1st time in publication structure. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes could signify a big new healing aim within the keep an eye on of epilepsy.

Astrocytes and Epilepsy contains history explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and proof from either human tissue experiences and animal versions linking sensible adjustments in astrocytes to epilepsy. fantastically labelled diagrams are provided and correct figures from the literature are reproduced to clarify key findings and ideas during this speedily rising box. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking good care of sufferers with epilepsy.

  • Presents the 1st accomplished booklet to synthesize old and up to date learn on astrocytes and epilepsy into one coherent volume
  • Provides a superb source at the box of astrocyte biology and astrocyte-neuron interactions
  • Details capability healing goals, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

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